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AI Builders 日报 — 8月22日

追踪 AI 领域真正在做事的人,而不是空谈者。


今日思考

本周医学领域密集发生了四件独立突破——个性化制药、基因疗法、细胞疗法等——表面看是四个不相关的事件,但底层是同一件事:医学正在变得可编程、从"适用于所有人的药"转向"为一个人写的药"。这和 AI 的方向高度共振:大模型从通用走向垂直定制,医学从通用疗法走向个性化方案。两个领域在同一个结构性转变里。


产品与发布

Mini 浏览器

Guillermo Rauch(Vercel CEO)用 fx.sh 和开源模型开发了一款极简个人浏览器 Mini,用于屏幕共享、直播测试等场景,避免主流浏览器的"膨胀"和状态积累。他首次体验到这类模型有多便宜、同时多好——并预言开源和本地模型将深刻改变"个人软件"的经济逻辑,"花 25000 美元取消一个 10 美元订阅"在企业里是真实存在的。faviconx.com


观点与判断

Matt Shumer(AutoGPT 创始人)

  • 每个 Agent 公司都应该和 agentmail 合作 他因使用 Agent 操作 Gmail 导致账号被封,随后转向 agentmail。他提出:如果 Agent 默认有收件箱,能显著缩短用户获得价值的时间、降低流失率——可以直接转发内容、让 Agent 代注账号,而无需先交出自己的账号权限。faviconx.com

  • Agent 收件箱是降低流失率的关键 Agent 公司之间应该建立收件箱优先的合作关系,让用户从第一天就能感受到价值,而不是经历漫长的配置期。faviconx.com

Guillermo Rauch(Vercel CEO)

  • 开源模型让软件变得"自发性" 他认为开源和本地模型将根本性改变软件经济的动态——软件不再需要昂贵的订阅,用户可以在本地运行,成本结构彻底重构。faviconx.com

Peter Yang(AI 内容创作者)

  • 正在开发 /fuck-cancer AI 技能 他宣布正在构建一个帮助癌症患者及家属导航治疗过程、获取信息的 AI 技能,目前在向社区征集功能建议。这个方向指向 AI 在医疗健康领域的实际应用落地,而非泛泛的"AI 赋能医疗"。faviconx.com

  • 新一期 AI Evals 深度内容 他邀请了 sh_reya 和 HamelHusain(累计教 4500+ 工程师和产品经理学 evals)在节目中实时"拷打"他为自己创作者技能构建的 AI 评估体系,并展示了如何用 Claude Code 或 Codex 中的免费 Error Discovery 技能,将真实 AI 失败案例转化为可复用的评估用例。faviconx.com

gdb(AI 领域从业者)

  • Agent 采用速度惊人,很容易忘记进展有多快 他引用数据指出:不到一年前,一年用掉 100 亿 tokens 还是个大成就、能获得奖励牌;现在一周就能处理超过 100 亿 tokens。Agent 的采用速度之快令人难以置信。faviconx.com

X / Twitter

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rauchg
rauchg @rauchg
http://fx.sh now supports your @Grok & Codex subs
Test it out on a sandbox. Instant to install:


Pranit: fx v0.0.5:
▫️ 4.2% smaller (6.13mb)
▫️ Grok and Codex subscription support
▫️ Project-local skills
▫️ Improved security
▫️ Many bugfixes & QoL improvements

fx upgrade ⋅ curl -fsSL http://fx.sh/setup.sh | bash
http://fx.sh/changelog
amasad
amasad @amasad
Retweeted
MakerThrive MakerThrive
update: $28,000 now!!!! (in one day)
you guys are all amazing; going to work on performance and add a bunch of new features 🚀🫡
http://1milllionpixels.com
MakerThrive: it's been a wild day to say the least.
$24k in revenue from my weekend @Replit project i built on my iphone.
grab your spot: http://1milllionpixels.com
gdb
gdb @gdb
towards giving our customers the lowest price on the market for any task, as well as the highest ceiling on capability

OpenAI: As we continue to push the frontier of capabilities while improving efficiency, we're dropping API and credit pricing of GPT-5.6 Sol by over 20% for the next 3 months.

swyx
swyx @swyx
🌍🔫👩‍🚀

Dylan Patel: God damnit, every one of my AI founder friends who actually have revenue are now just transforming into neoclouds with value add on top
swyx
swyx @swyx
Retweeted
forget the grind. small iterative steps. do things forget the grind. small iterative steps. do things
Latent Space pod 'Exo: Harnesses should see their own code and logs — Alex Krentsel'
Interesting. Valuable. Be sure to get to the part where @swyx connects the Smalltalk/Lisp dots.
In 2026 LLMs are an invaluable part, but only a part, of systems we need to build -- especially if we want to avoid jailbreaking
swyx
swyx @swyx
Retweeted
Latent.Space Latent.Space
You are not sufficiently appreciating the scope of RSI.
Here's a brief prehistory. http://x.com/i/article/2091070545441783808
swyx
swyx @swyx
Retweeted
Dan McAteer Dan McAteer
AI engineers: the model absorbs the harness, and the harness transforms into an interface for human attention.
> The 'attention-interface'.
That's what 'The Evolution of the Agent Harness' is about.
A post written for @latentspacepod.
ylecun
ylecun @ylecun
Retweeted
Neil Stone Neil Stone
Can't tell if measles vaccine works
petergyang
petergyang @petergyang
In my next episode, I asked @sh_reya and @HamelHusain (taught evals to 4,500+ engineers and PMs) to roast the AI evals that I built for my creator skills live.

They also showed me how anyone can use their free Error Discovery skill in Claude Code or Codex to turn real AI failures into reusable evals.

📌 Subscribe to get the full episode tomorrow: https://www.youtube.com/@PeterYangYT?sub_confirmation=1
petergyang
petergyang @petergyang
Retweeted
Peter Yang Peter Yang
In my next episode, I asked @sh_reya and @HamelHusain (taught evals to 4,500+ engineers and PMs) to roast the AI evals that I built for my creator skills live.
They also showed me how anyone can use their free Error Discovery skill in Claude Code or Codex to turn real AI failures into reusable evals.
📌 Subscribe to get the full episode tomorrow: https://www.youtube.com/@PeterYangYT?sub_confirmation=1
petergyang
petergyang @petergyang
As both a US and Canadian citizen, it sure sucks to see the two countries fight like this.
garrytan
garrytan @garrytan
Retweeted
dnap dnap
David Sacks explains the step by step playbook for banning open source models
"An open source ban is coming. They're not going to call it that. They're going to say that we simply have to apply the same standards to open models that we apply to closed."
"Here's how they do it step by step. Let me explain how regulatory capture actually works."
"Dario wants an FDA for AI. But he doesn't have enough political support for that. So instead, they do this Trojan horse of a FINRA for AI. They call it self-regulating. It's not really, but anyway, that gets them off the ground."
"Now they've created the standard setting organization. Now they've got pre-release model testing. Then the pressure grows to codify that in law. And then what they do is they say, look, all these standards need to apply equally to all models."
"But here's the problem with that. Open models and closed models, as you know, are technologically different."
ylecun
ylecun @ylecun
Retweeted
Afshine Emrani  MD FACC Afshine Emrani MD FACC
1/ I'm a cardiologist. I've practiced for twenty-five years, through a lot of "breakthroughs" that turned out to be press releases. So understand the weight of what I'm about to say: I have never seen a single week in medicine like the one we just lived through.
In the span of a few days, four separate scientific breakthroughs landed. The stock market treated them as four unrelated stories and sent a handful of biotech companies soaring. But that's the shallow read. Look closer and they are not four stories at all. They are four faces of the same story — the biggest shift in medicine since the discovery of antibiotics.
Medicine is becoming programmable. Individualized. Written for one human being instead of the average of millions.
Let me walk you through exactly what happened, in plain language, and show you where this is actually headed. Because the future arrived quietly this week, and most people scrolled right past it.
amasad
amasad @amasad
Retweeted
MakerThrive MakerThrive
in COMPLETE disbelief 🤯
no signs of slowing down 🚀
223,000 pixels sold of 1M total
built on MY iphone via @Replit
http://1milllionpixels.com
MakerThrive: i credit all of the success today to @jonathan_wilke's http://outbid.lol
i got lucky, hundreds of others didn't
extremely grateful 🙏
swyx
swyx @swyx
Retweeted
AI Engineer AI Engineer
Live now: our AI Architects, AI Factories Track from AI Engineer World's Fair 2026.
Thesis: the model is the easy part of the factory.
https://www.youtube.com/watch?v=rbjWzZK2LU0&list=PLcfpQ4tk2k0VeXEfQTcsO7buehrFvQAKj
- The Agent Behind the Curtain: Building the Oz Cloud Agent Platform: Safia Abdalla, Warp
- FinOps for AI Agents: Who Spent All the Tokens?: Tisha Chawla + Susheem Koul, Microsoft
- What If Your Chip Design Team Moved Like a Single Body?: Abduallah Mohamed, AIDAChip
- Preferences Over Benchmarks: Model Routing: Archana Kamath + Tyler Gillam, DigitalOcean
- Coding Agents Don't Scale Themselves. Neither Do Your Teams.: @patrickdebois, Tessl
- Agent Frameworks Considered Harmful: @remilouf, .txt
- Inside 847 Production Clinical AI Notes: Sebastian Fox, Composo
- Give the Agent a Budget, Not a Token: @edorado93, Anthropic
amasad
amasad @amasad
“Pretty soon” turned out to be 3 months.

amasad
amasad @amasad
Retweeted
Samuel Spitz Samuel Spitz
I still can’t believe they made Replit free
Replit ⠕: Replit Free Mode, powered by @OpenAI GPT-5.6 Luna.
Let’s make intelligence accessible to everyone.
ylecun
ylecun @ylecun
Retweeted
Noah Smith 🐇🇺🇸🇺🇦🇹🇼 Noah Smith 🐇🇺🇸🇺🇦🇹🇼
Incredible statistic
Don Winslow: Donald Trump is responsible for 1/3 of the federal debt.
The other 44 Presidents together equal the other 2/3
garrytan
garrytan @garrytan
Retweeted
Lee Kuan Yimby Lee Kuan Yimby
Nobody against data centers understands data centers.
Nobody against Flock cameras understands how they work or what they do.
Nobody demanding Medicare for All knows how Medicare currently functions or what it would cost.
Nobody saying “tax the rich” knows how much the rich already pay in taxes.
Nobody saying “seize the means of production” knows how to build or maintian the means of production.
Nobody saying “fund education” knows how much we already spend on education.
Nobody saying “no new wars” understands geopolitics.
Nobody saying “ban corporate landlords” knows what percentage of homes corporations actually own.
Nobody saying “developers are greedy” understands why housing costs what it does.
Nobody demanding price controls understands what happens to supply when you cap prices.
Nobody saying billionaires could “end homelessness” knows what governments already spend on homelessness.
Nobody saying “just build public housing” knows what it costs government to build a single unit.
Nobody demanding free college knows how much universities already receive from taxpayers.
Nobody saying “just nationalize it” can look at what the government already operates and understand why that's a bad idea.
Modern politics increasingly rewards having the strongest possible opinion about something you have spent the least possible time trying to understand.
The American voter increasingly demand sensationalism and they have no idea how wealthy they are compared to the rest of the world.
They may end up being the cause of their self inflicted belt tightening and they are in no way ready for an ounce of actual poverty.
We need immediate competence to take over sensationalism and social media, especially tiktok is the enemy of that.
Governor Hochul Press Office: HOCHUL ENACTS NATION’S FIRST STATEWIDE DATA CENTER MORATORIUM
rauchg
rauchg @rauchg
I used 𝚏𝚡 to build Mini, a personal web browser.

Many times I need to screen share, stream, or just test something without the 'bloat' and state of my browser. So I go Mini.

This was a cool test for http://fx.sh and open models. It was the first time I experienced how cheap, but also how *good* these things can be.

'Personal software' is a hot topic. "I spent $25,000USD to cancel my $10 XYZ subscription" is a real thing 😂 (especially in Enterprises these days).

But I think open and local models will change this dynamic very profoundly. Software will really become spontaneous.

ps: shoutout to Orion browser who inspired me with 'focus mode'. I wanted my browser to be even more minimal, hackable, and run on Chromium.
gdb
gdb @gdb
agentic adoption has been super fast, easy to forget how far the field has come

Florian Brand: Not even a year ago, 10B tokens in a year was a big achievement and got you a plaque

Now I do >10B tokens a week
ylecun
ylecun @ylecun
Retweeted
Kenneth Roth Kenneth Roth
Why did far more Americans die of Covid-19 than people in other rich nations? Inadequate testing, erratic lockdowns, poor contact tracing, and too little willingness to be vaccinated. Yet Republicans, rather than focus on these real problems, attack Fauci. https://trib.al/pwjSmHk
petergyang
petergyang @petergyang
I’m working on a new AI skill.

It’s called /fuck-cancer

Goal is to help patients and their family navigate this whole process and stay informed.

What should I include in it?
ylecun
ylecun @ylecun
Retweeted
Simon Maechling Simon Maechling
I’m a scientist.
Every time I hit “post,” I hesitate.
Not because I doubt the science.
But because I know what’s coming.
I know someone will call me a shill.
Someone will tell me I’ve been bought by industry.
Someone will explain my own field to me after watching a 90-second video.
Someone will demand a source, then reject the source because they don’t like who funded it.
And someone will confidently tell thousands of people that I’m lying.
That is the strange reality of communicating science online.
You spend years learning how uncertain science can be.
Then you enter a world where the most confident person in the comments often knows the least.
But I keep hitting “post.”
Because if scientists decide that communicating science isn’t worth the abuse, the people with the least hesitation get to explain science instead.
And that seems far more dangerous.
garrytan
garrytan @garrytan
Retweeted
Kane 謝凱堯 Kane 謝凱堯
Watching Berkeley progressives protest turning this abandoned lot littered with crackheads into student housing for half a decade was radicalizing.
Tyler | Kenji Capital: I don't think people realize...
But this has risen out of the ground at People's Park in Berkeley.
After DECADES of protests, lawsuits, political fights, and failed attempts to develop the site...
UC Berkeley is building housing for 1,100+ students here.
The project includes:
amasad
amasad @amasad
Retweeted
Raouf Chebri Raouf Chebri
I can now import @mattpocockuk's all 36 skills on Replit right from GitHub.
Shout out to Matt for his awesome skills repo. https://github.com/mattpocock/skills
rauchg
rauchg @rauchg
San Francisco is a paradise on Earth
garrytan
garrytan @garrytan
Retweeted
Peter J. Hasson Peter J. Hasson
“Mother credits Flock Safety cameras for aiding in conviction of daughter's killer”
https://www.rocketcitynow.com/article/news/state/mother-credits-flock-safety-cameras-for-aiding-in-conviction-of-daughters-killer/525-ec1b2c74-3ddb-4d4b-bfd3-3ade0dead6e5
amasad
amasad @amasad
Retweeted
Kenneth Dredd Kenneth Dredd
Get in the bin ya flog
dnap: Chamath says Silicon Valley lost what made it great and only cares about money now
"Silicon Valley has completely lost what made it great. It was a place for weirdos, for people at the fringes, for people that really were idealistic. And it has become something that's far from
swyx
swyx @swyx
Retweeted
Joon Sung Park Joon Sung Park
I’ve always thought of simulation as painting a portrait. A great portrait helps you understand its subject beyond what’s visible on the surface.
This new scaling law will let us paint the highest-resolution portrait of our society yet. That’s worth getting excited about.
swyx: I think its easy to say "Simulation is a new scaling law" and treat it as marketing hyperbole, but midway along this interview you can hear me go from somewhat shitposting to very very serious.
I am 2 years late to this but finally understand why @karpathy and @drfeifei backed
mattshumer_
mattshumer_ @mattshumer_
I got my Gmail banned by using it with an agent.

@agentmail is the way to go!

Adi Singh: http://x.com/i/article/2091234629437227008
mattshumer_
mattshumer_ @mattshumer_
Every agent company should be partnering with @agentmail.

If an agent has an inbox by default, it dramatically decreases time to value and cuts churn.

I can just fwd stuff, have it sign up for accounts, not have to give it my stuff to start getting value.

Adi Singh: http://x.com/i/article/2091234629437227008

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